immunobiology of virulent and avirulent clones of Leishmania major. by Cheryl Ann Scott

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Published by Brunel University in Uxbridge .

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ContributionsBrunel University. Department of Applied Biology.
The Physical Object
Pagination311p. :
Number of Pages311
ID Numbers
Open LibraryOL14472643M

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The immunobiology of virulent and avirulent clones of Leishmania major. By C.A Scott. Abstract. SIGLEAvailable from British Library Document Supply Centre- DSC:DX / BLDSC - British Library Document Supply CentreGBUnited Kingdo The immunobiology of virulent and avirulent clones of Leishmania major.

(Thesis) Scott CA. Publisher: Brunel University [] Metadata Source: The British Library Type: Thesis. Abstract. No abstract supplied. Menu. Formats. Abstract. EThOS. About. The immunobiology of virulent and avirulent clones of Leishmania major. Author: Scott, Cheryl Ann.

ISNI: Awarding Body: Brunel University Current Institution: Brunel University Date of Award: Availability of Full Text: ?uin= BALB/c mice, which are normally highly susceptible to growth of Leishmania mexicana parasites in vivo, can be vaccinated with avirulent temperature-sensitive mutants of L.

mexicana so that   The existence of virulent and avirulent clones of L. tro- pica (8) and L. braziliensis guyanensis (Keithly, unpublished observations) in- dicates that the genotype of the para- site is at least as important as that of the :// The LmSTI1 (a Leishmania homolog of a yeast stress-inducible protein 1) antigen stimulated mixed Th1/Th2 responses in lymph node cells of BALB/c mice infected with L.

major and the sera of these animals contained high titers of IgE, IgG1 and IgG2a anti-LmSTI1 antibodies (Webb et al., ). As is the case for LACK, LmSTI1 is readily recognized Giemsa staining showed the failure of avirulent but not virulent parasites to transform to the amastigote stage in infected host cells.

with both virulent and avirulent modulating the expression Kimsey PB, Theodos CM, Mitchen TK, Turco SJ, Titus RG. An avirulent lipophosphoglycan-deficient Leishmania major clone induces CD4+ T cells which protect susceptible BALB/c mice against infection with virulent L.

major. Infect Immun. Dec;61(12) [ Links ] ?script=sci_arttext&pid=S Susceptibility to Leishmania major in IL-4 transgenic mice is not correlated with the lack of a Th1 immune response.

Immunology and Cell Biology, [ Links ] Leal LM, Moss DW, Kuhn R, Muller W & Liew FY (). Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major ?script=sci_arttext&pid=SX Please read our short guide how to send a book to Kindle.

Save for later. You may be interested in Powered by Rec2Me Most frequently terms. cells cell antigen immune disease response antigens antibodies immunity immunobiology of virulent and avirulent clones of Leishmania major. book animals ?dsource=recommend. Sacks, D. L., and da Silva, R.

P.,The generation of infective stage Leishmania major promastigotes is associated with the cell-surface expression and release of a developmentally regulated glycolipid, J.

Immunol. – PubMed Google Scholar The parasites then convert to obligate intracellular amastigotes, which reside and multiply intercellularly in macrophage phagolysosomes. 1 Leishmania-infected macrophages either remain locally in the skin and cause cutaneous leishmaniasis (L.

major, L. amazonenesis, L. mexicana, L. braziliensis), or they disseminate to distant locations Leishmaniasis is a neglected disease resulting in a global morbidity of 2, thousand Disability-Adjusted Life Years and a mortality rate of approximat per year. Among the three clinical forms of leishmaniasis (cutaneous, mucosal, and visceral), visceral leishmaniasis (VL) accounts for the majority of mortality, as if left untreated VL is almost always :// SUMMARY The gram-positive bacterium Listeria monocytogenes is the causative agent of listeriosis, a highly fatal opportunistic foodborne infection.

Pregnant women, neonates, the elderly, and debilitated or immunocompromised patients in general are predominantly affected, although the disease can also develop in normal individuals.

Clinical manifestations of invasive listeriosis are usually   Under a variety of stress conditions, Leishmania species display some morphological and biochemical features characteristic of mammalian programmed cell death or necrosis.

Nitroheteroaryl-1,3,4-thiadiazoles induce cell death in Leishmania major (L. major).Putative mechanisms of action of these compounds were investigated in vitro at cellular and molecular :// Although a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no universally acceptable, safe, and effective vaccine against the disease.

This strongly suggests that we still do not completely understand the factors that control and/or regulate the development and sustenance of anti-Leishmania immunity, particularly those associated with In this study, a Leishmania hypothetical protein, LiHyS, was evaluated regarding its antigenicity, immunogenicity and protective efficacy against visceral leishmaniasis (VL).

Regarding antigenicity, immunoblottings and an enzyme-linked immunosorbent assay using human and canine sera showed high sensitivity and specificity values for the recombinant protein (rLiHyS) in the diagnosis of ://   Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host.

Infect. Immun. 61, – [Europe PMC free article] [Google Scholar] Afonso L. C., Scharton T. M., Vieira L. Q., Wysocka M., Trinchieri G., Scott P. The adjuvant effect of interleukin in a vaccine against Leishmania :// Chakrabarty R, Mukherjee S, Lu HG, McGwire BS, Chang KP, Basu MK.

Kinetics of entry of virulent and avirulent strains of Leishmania donovani into macrophages: a possible role of virulence molecules (gp63 and LPG). Journal of Parasitology. Aug. ;82(4) Chen DQ, Kolli BK, Yadava N, Lu HG, Gilman-Sachs A, Peterson DA, Chang :// Virulent strains of E.

histolytica have high densities of LPPG on their surfaces; in contrast, avirulent strains have low densities of this molecule on their surfaces (10–13). The structure of LPPG is similar to that of two other PAMPs, lipophosphoglycan (LPG) from Leishmania A virulent line of L.

donovani Acid phosphatase activity of virulent and avirulent clones of Leishmania donovani promastigotes. Infect Immun – Mendez S, Shevach EM, Sacks DL () CD4 + CD25 + regulatory T cells control Leishmania major persistence and immunity. Nature – Belkaid Y () The role of CD4 Aebischer T, Moody SF, Handman E.

Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host. Infect Immun. Jan; 61 (1)– [PMC free article] Bogdan C, Gessner A, Röllinghoff M.

Cytokines in leishmaniasis: a complex network of stimulatory and inhibitory interactions. :// Its orthologues were upregulated in metacyclic promastigotes of Leishmania mexicana M and in a virulent strain (as compared to its avirulent kin) of Leishmania major LV Confirming this and highlighting its potential importance, LmxM orthologue was one of only four genes consistently upregulated in both fly-derived and axenically Characterization of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species Symons, F.M., P.J.

Murray, H. Ji, R.J Leishmania major: expression and gene structure of the glycoprotein 63 molecule in virulent and avirulent clones and strains Murray, P.J., E.

Handman, T.A. Glaser, and T.W Mannose receptor (MR) is a member of pattern-recognition receptors (PRRs), which plays a significant role in immunity responses. Much work on MR has been done in mammals and birds while little in fish. In this report, a MR gene (designated as zfMR) was cloned from zebra fish (Danio rerio), which is an attractive model for the studies of animal diseases.

The full-length cDNA of zfMR contains Katakura K, Kobayashi A. Acid phosphatase activity of virulent and avirulent clones of Leishmania donovani promastigotes. Infect Immun ; 56(11) Olivier M, Gregory DJ, Forget G. Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view.

Clin Microbiol Rev ; 18(2 Interestingly, IL + Foxp3 − CD4 + regulatory cells with a Th1 cell phenotype recently have been demonstrated to be induced during the exposure of mice to a nonhealing strain of Leishmania major and to play a major role in determining host susceptibility (see Anderson et al.

on p. of this issue). //2///Conventional-T-bet-Foxp3-Th1-cells-are-the-major. Leishmania infantum: A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL).Human infections are confined almost entirely to children.

This parasite is commonly seen in dogs, other Canidae, and porcupines with humans considered only an accidental :// This chapter focuses on the sources, the regulation, the spectrum of activities, and the viral and microbial targets of reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs) generated by mammalian host cells.

With respect to the control of infectious agents, the two most important oxygen-dependent pathways for the generation of antiviral or antimicrobial effector The 13 chapters of the book have been grouped according to subject.

The first five chapters deal with Leishmania and are followed by two chapters on Try­ ponosoma cruzi, two on the malarial parasites, and two on the Coccidia. The fmal two chapters cover the Microsporidia and chemotherapy, :// Leishmania major: Expression and gene structure of the glycoprotein 63 molecule in virulent and avirulent clones and strains.

Experimental Parasitology. Leishmania donovani: A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL).The sandfly genera Phlebotomus and Lutzomyia are the vectors.

Leishmania: A genus of flagellate protozoa comprising several species that are pathogenic for sms of this genus have an Book DOI: / Chapter DOI: /ch2 MyBook is a cheap paperback edition of the original book and will be sold at uniform, low :// Next, we examined ERH1 expression in response to inoculation with a virulent or an avirulent bacterial pathogen.

Six-week-old Col-0 wild-type plants were inoculated with the virulent P. syringae pv maculicola strain ES or the congenic avirulent strain carrying avrRpm1, which elicits RPM1-dependent HR and resistance (Grant et al., ) Prevention -- References -- Index.;The first in a new series created to acknowledge the explosion of knowledge in fields related to infectious disesases and clinical microbiology.

Thirteen contributions focus on organisms which are of major medical importance in this country or which have contributed to an understanding of :// The Trypanosomatidae family includes the genera Trypanosoma and Leishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector.

Trypanosoma brucei gambiense, Trypanosoma cruzi, and Leishmania spp. are important human pathogens causing human African trypanosomiasis (HAT or sleeping sickness), Chagas’ disease, and various clinical PspA is required for virulence in C3H/HeN (Nramp1 +) mice.

6 weeks old C3H/HeN mice were inoculated i.p. with 3 × 10 3 cfu wild‐type (), ΔpspA () or ΔpspA /pJK strains of S. Typhimurium s. Two groups of five mice were assayed independently.

A statistical test of mouse survival indicated that the ΔpspA mutant is attenuated for virulence (P Formation of anti- Toxoplasma gondii HSP70 (TgHSP70) antibody cross-reactive to mouse HSP70 (mHSP70) was observed in the sera of BALB/c (a resistant strain) and C57BL/6 (B6; a susceptible strain) mice after peroral infection with T.

gondii cysts of the Fukaya strain. The levels of anti-mHSP70 immunoglobulin G (IgG) autoantibody production in B6 mice were higher than those in BALB/c :// ().

Macrophage activation: lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-alpha. Macrophage deactivation by interleukin (). The initial defense against infection with M. tuberculosis, once it reaches the lower respiratory tract, is the alveolar macrophage, and an overview of the interactions between macrophages and mycobacteria is given in Table cell is capable of inhibiting growth of the bacillus through phagocytosis, and, as will be discussed later, of participating in a broader context of cellular.

TAP-1 −/− mice fail to mount protective CD8 T cell responses and display enhanced susceptibility to infection with an avirulent strain of T.

gondii. (A) WT (n = 5), TAP-1 −/− (n = 5), and CD8 −/− (n = 5) mice were vaccinated with 2 × 10 5 tachyzoites of the attenuated ts-4 parasite strain and challenged 2 wk later with virulent   Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF.

Visit to get more information about this book, to buy it in print, or to download it as a free PDF Leishmania major: Expression and gene structure of the glycoprotein 63 molecule in virulent and avirulent clones and strains Academic Article Les IAP au cœur de la signalisation NF-κB Academic Article Location of sequences in the nar promoter of Escherichia coli required for regulation by

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